Publikationen 2003

Belyanskaya, L. L., Delattre, O. & Gehring, H. Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process. Exp. Cell Res. 288, 374-381 (2003).

Binz, H. K., Stumpp, M. T., Forrer, P., Amstutz, P. & Plückthun, A. Designing repeat proteins: Well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J. Mol. Biol. 332, 489-503 (2003).

Bischofberger, P., Han, W., Feifel, B., Schonfeld, H. J. & Christen, P. D-Peptides as inhibitors of the DnaK/DnaJ/GrpE chaperone system. J. Biol. Chem. 278, 19044-7 (2003).

Buscaglia, M., Schuler, B., Lapidus, L. J., Eaton, W. A. & Hofrichter, J. Kinetics of intramolecular contact formation in a denatured protein. J. Mol. Biol. 332, 9-12 (2003).

Caflisch, A. Folding for binding or binding for folding? Trends Biotechnol. 21, 423-425 (2003).

Cavalli, A., Haberthur, U., Paci, E. & Caflisch, A. Fast protein folding on downhill energy landscape. Protein Sci. 12, 1801-1803 (2003).

Cesaro-Tadic, S., Lagos, D., Honegger, A., Rickard, J. H., Partridge, L. J., Blackburn, G. M. & Plückthun, A. Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library. Nat. Biotechnol. 21, 679-685 (2003).

Ciatto, C., Capitani, G., Tissot, A. C., Pecorari, F., Plückthun, A. & Grütter, M. G. Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db. FEBS Lett. 543, 11-15 (2003).

Deyev, S. M., Waibel, R., Lebedenko, E. N., Schubiger, A. P. & Plückthun, A. Design of multivalent complexes using the barnase*barstar module. Nat. Biotechnol. 21, 1486-1492 (2003).

Di Paolo, C., Willuda, J., Kubetzko, S., Lauffer, I., Tschudi, D., Waibel, R., Plückthun, A., Stahel, R. A. & Zangemeister-Wittke, U. A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity ERRATUM: Vol. 10, 2004, 2579. Clin. Cancer Res. 9, 2837-2848 (2003).

Dutzler, R., Campbell, E. B. & MacKinnon, R. Gating the selectivity filter in ClC chloride channels. Science 300, 108-12 (2003).

Ewert, S., Honegger, A. & Plückthun, A. Structure-based improvement of the biophysical properties of immunoglobulin Vh domains with a generalizable approach. Biochemistry 42, 1517-1528 (2003).

Ewert, S., Huber, T., Honegger, A. & Plückthun, A. Biophysical properties of human antibody variable domains. J. Mol. Biol. 325, 531-553 (2003).

Forrer, P., Stumpp, M. T., Binz, H. K. & Plückthun, A. A novel strategy to design binding molecules harnessing the modular nature of repeat proteins. FEBS Lett. 539, 2-6 (2003).

Gemperli, A. C., Dimroth, P. & Steuber, J. Sodium ion cycling mediates energy coupling between complex I and ATP synthase. Proc. Natl. Acad. Sci. USA 100, 839-844 (2003).

Gorfe, A. A. & Jelesarov, I. Energetics of sequence-specific protein-DNA association: Computational analysis of integrase Tn916 binding to its target DNA. Biochemistry 42, 11568-11576 (2003).

Grimshaw, J. P. A., Jelesarov, I., Siegenthaler, R. K. & Christen, P. Thermosensor action of GrpE - The DnaK chaperone system at heat shock temperatures. J. Biol. Chem. 278, 19048-19053 (2003).

Gsponer, J., Haberthur, U. & Caflisch, A. The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35. Proc. Natl. Acad. Sci. USA 100, 5154-5159 (2003).

Gygi, D., Zumstein, P., Grossenbacher, D., Altwegg, L., Lüscher, T. F. & Gehring, H. Human connective tissue growth factor expressed in Escherichia coli is a non-mitogenic inhibitor of apoptosis. Biochem. Biophys. Res. Commun. 311, 685-690 (2003).

Haberthur, U., Majeux, N., Werner, P. & Caflisch, A. Efficient evaluation of the effective dielectric function of a macromolecule in aqueous solution. J. Comput. Chem. 24, 1936-1949 (2003).

Han, W. & Christen, P. Mechanism of the targeting action of DnaJ in the DnaK molecular chaperone system. J. Biol. Chem. 278, 19038-43 (2003).

Han, W. & Christen, P. Interdomain communication in the molecular chaperone DnaK. Biochem. J. 369, 627-34 (2003).

Knipp, M., Braun, O., Gehrig, P. M., Sack, R. & Vasak, M. Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation. J. Biol. Chem. 278, 3410-3416 (2003).

Kohl, A., Binz, H. K., Forrer, P., Stumpp, M. T., Plückthun, A. & Grütter, M. G. Designed to be stable: Crystal structure of a consensus ankyrin repeat protein. Proc. Natl. Acad. Sci. USA 100, 1700-1705 (2003).

Levy, Y. & Caflisch, A. Flexibility of monomeric and dimeric HIV-1 protease. J. Phys. Chem. 107, 3068-3079 (2003).

Lipman, E. A., Schuler, B., Bakajin, O. & Eaton, W. A. Single-molecule measurement of protein folding kinetics. Science 301, 1233-1235 (2003).

Madani, R., Kozlov, S., Akhmedov, A., Cinelli, P., Kinter, J., Lipp, H. P., Sonderegger, P. & Wolfer, D. P. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol. Cell. Neurosci. 23, 473-494 (2003).

Matsuura, T. & Plückthun, A. Selection based on the folding properties of proteins with ribosome display. FEBS Lett. 539, 24-28 (2003).

Marti, D.N. & Bosshard, H. R. Electrostatic interactions in leucine zippers: thermodynamic analysis of the contributions of Glu and His residues and the effect of mutating salt bridges. J. Mol. Biol. 330, 621-37 (2003)

Milev, S., Gorfe, A. A., Karshikoff, A., Clubb, R. T., Bosshard, H. R. & Jelesarov, I. Energetics of sequence-specific Protein-DNA association: Binding of integrase Tn916 to its target DNA. Biochemistry 42, 3481-3491 (2003).

Milev, S. G., A. A. Karshikoff, A. Clubb, R. T. Bosshard, H. R. & Jelesarov, I. Energetics of sequence-specific protein-DNA association: conformational stability of the DNA binding domain of integrase Tn916 and its cognate DNA duplex. Biochemistry 42, 3492-502 (2003).

Molinari, F., Meskanaite, V., Munnich, A., Sonderegger, P. & Colleaux, L. Extracellular proteases and their inhibitors in genetic diseases of the central nervous system. Human Molecular Genetics 12, R195-R200 (2003).

Müntener, K. Z., R. Csucs, G. & Baici, A. The alternative use of exons 2 and 3 in cathepsin B mRNA controls enzyme trafficking and triggers nuclear fragmentation in human cells. Histochem. Cell Biol. 119, 93-101 (2003).

Nishlyama, M., Vetsch, M., Puorger, C., Jelesarov, I. & Glockshuber, R. Identification and characterization of the chaperone-subunit complex-binding domain from the type 1 pilus assembly platform FimD. J. Mol. Biol 330, 513-525 (2003).

Paci, E., Cavalli, A., Vendruscolo, M. & Caflisch, A. Analysis of the distributed computing approach applied to the folding of a small beta peptide. Proc. Natl. Acad. Sci. 100, 8217-8222 (2003).

Rao, F. & Caflisch, A. Replica exchange molecular dynamics simulations of reversible folding. J. Chem. Physics 119, 4035-4042 (2003).

Roschitzki, B. & Vasak, M. Redox labile site in a Zn-4 cluster of Cu-4,Zn-4-metallothionein-3. Biochemistry 42, 9822-9828 (2003).

Steuber, J. The C-terminally truncated NuoL subunit (ND5 homologue) of the Na⁺ -dependent complex I from Escherichia coli transports Na+. J. Biol. Chem. 278, 26817-26822 (2003).

Stumpp, M. T., Forrer, P., Binz, H. K. & Plückthun, A. Designing repeat proteins: Modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family. J. Mol. Biol. 332, 471-487 (2003).

Tolan, D. R., Schuler, B., Beernink, P. T. & Jaenicke, R. Thermodynamic analysis of the dissociation of the aldolase tetramer substituted at one or both of the subunit interfaces. Biol. Chem. 384, 1463-1471 (2003).

Uk, B., Taufer, M., Stricker, T., Settanni, G., Cavalli, A. & Caflisch, A. in International Symposium on Cluster Computing and the Grid (CCGRID) (2003).

Vasak, M. New insights into the role of metal-thiolate clusters in neuronal growth inhibitory factor (metallothionein-3). Journal of Inorganic Biochemistry 96, 25-25 (2003).

Wannier-Morino, P., Rager, G., Sonderegger, P. & Grabs, D. Expression of neuroserpin in the visual cortex of the mouse during the developmental critical period. Eur. J. Neurosci. 17, 1853-1860 (2003).

Werner, P. & Caflisch, A. A sphere-based model for the electrostatics of globular proteins. J. Am. Chem. Soc. 125, 4600-4608 (2003).

Zhang, B., Georgiev, O., Hagmann, M., Gunes, C., Cramer, M., Faller, P., Vasak, M. & Schaffner, W. Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Mol. Cell. Biol. 23, 8471-8485 (2003).

Zwicky, R., Müntener, K., Csucs, G., Goldring, M. B. & Baici, A. Exploring the role of 5'-alternative splicing and of the 3'-untranslated region of cathepsin B mRNA. Biol. Chem. 384, 1007-1018 (2003).