Publications of the Sonderegger group

Gisler, C., Lüscher, D., Schätzle, P., Dürr, S., Baici, A., Gallicotti, G., Reif, R., Bolliger, MF., Kunz, B. & Sonderegger, P. Zymogen activation of neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans. Biochem J. 2013 Apr 5. [Epub ahead of print]

Schätzle, P., Wuttke, R., Ziegler, U. & Sonderegger, P. Automated quantification of synapses by fluorescence microscopy. J. Neurosci. Methods 204, 144-149 (2012).

Steuble, M., Diep, TM., Schätzle, P., Ludwig, A., Tagaya, M., Kunz, B. & Sonderegger, P. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open. 1, 761-774 (2012). 

Bütikofer, L. Zurlinden , A., Bolliger, MF., Kunz, B. & Sonderegger, P. Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia. FASEB J. 12, 4378-4393 (2011).

Schätzle, P., Ster J., Verbich, D., Mc Kinney, RA., Gerber, U., Sonderegger, P. & Mateos, JM. Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA 1 pyramidal cells. J Physiol. 589, 4353-4364 (2011). 

Bányai L, Sonderegger P & Patthy L. Agrin binds BMP2, BMP4 and TGFbeta1. PLoS One. 5(5):e10758 (2010).

Bolliger, MF., Zurlinden, A., Lüscher, D., Bütikofer, L., Shakhova, O., Francolini, M., Kozlov, SV., Cinelli, P., Stephan, A., Kistler, AD., Rülicke, T., Pelczar, P., Ledermann, B., Fumagalli, G., Gloor, SM., Kunz, B. & Sonderegger, P. Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J Cell Sci. 123, 3944-3955 (2010).

Dityatev, A., Schachner, M. & Sonderegger, P. The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci. 11, 735-746 (2010).

Steuble M, Gerrits B, Ludwig A, Mateos JM, Diep TM, Tagaya M, Stephan A, Schätzle P, Kunz B, Streit P & Sonderegger P. Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics. 10, 3775-3788 (2010).

Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C & Meinl E. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci U S A. 106, 8302-8327 (2009).

Ludwig, A., Blume, J., Diep, TM., Yuan, J., Mateos, JM., Leuthäuser, K., Steuble, M., Streit, P. & Sonderegger, P. Calsyntenins mediate TGN exit of APP in a Kinesin-1-dependent manner. Traffic  10, 572-589 (2009).

Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Lüscher D, Hettwer S, Wölfel J, Ladner AP, Ster J, Gerber U, Rülicke T, Kunz B & Sonderegger P. Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell  136, 1161-1171 (2009).

Coutelier, M., Andries, S., Ghariani, S., Dan, B., Duyckaerts, C., van Rijckevorsel, K., Raftopoulos, C., Deconinck, N., Sonderegger, P., Scaravilli, F., Vikkula, M. & Godfraind, C. Neuroserpin mutation causes electrical status epilepticus of slow-wave sleep. Neurology 71, 64-66 (2008). 

Frischknecht, R., Fejtova, A., Viesti, M., Stephan, A. & Sonderegger, P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J. Neurosci. 28, 1568-1579 (2008).

Lebeurrier, N., Launay, S., Macrez, R., Maubert, E., Legros H., Leclerc, A., Jamin, SP., Picard, JY., Marret, S. Laudenbach, V., Berger, P., Sonderegger, P., Ali, C., di Clemente, N. & Vivien, D. Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin. J Cell Sci. 121, 3357-3365 (2008).

Reif, R., Sales, S., Dreier, B., Lüscher, D., Wölfel, J., Gisler, C., Baici, A., Kunz, B. & Sonderegger, P. Purification and enzymological characterization of murine neurotrypsin. Protein Expr. Purif. 61, 13-21 (2008).

Rindler, MJ., Xu, CF., Gumper, I., Cen, C., Sondergger, P. & Neubert, TA. Calsynthenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells. J. Histochem. Cytochem. 56, 381-388 (2008).

Stephan, A., Mateos, JM., Kozlov, SV., Cinelli, P., Kistler, AD., Hettwer, S., Rülicke, T. , Streit, P., Kunz, B. & Sonderegger, P. Neurotrypsin cleaves agrin locally at the synpase. FASEB J. 22, 1861-1873 (2008). 

Galliciotti, G., Glatzel, M., Kinter, J., Kozlov, SV., Cinelli, P., Rulicke, T. & Sonderegger, P. Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am J Pathol. 170, 1305-13 (2007). 

Gourfinkel-An, I., Duyckaerts, C., Camuzat, A., Meyrignac, C., Sondergger, P., Baulac, M. & Brice, A. Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. Neurology 69, 79-83 (2007).

Mörtl, M., Sonderegger, P., Diederichs, K. & Welte, W. The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction. Protein Sci 16, 2174-2183 (2007).

Reif, R., Sales, S., Hettwer, S., Dreier, B., Gisler, C., Wölfel, J., Lüscher, D., Zurlinden, A., Stephan, A., Ahmed, S., Baici, A., Ledermann, B., Kunz, B. & Sondergger, P. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J. 21, 3468-3478 (2007).

Sonderegger, P. & Patty, L. Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Science 16,1698 (2007).

Galliciotti, G. & Sonderegger, P. Neuroserpin. Frontiers in Bioscience 11, 33-45 (2006).

Konecna, A., Frischknecht, R., Kinter, J., Ludwig, A., Steuble, M., Meskenaite, V., Indermuhle, M., Engel, M., Cen, C., Mateos, J. M., Streit, P. & Sonderegger, P. Calsyntenin-1 docks vesicular cargo to Kinesin-1. Mol. Biol. Cell 17, 3651-3663 (2006).

Simonin, Y., Charron, Y., Sonderegger, P., Vassalli, JD. & Kato AC. An inhibitor of serine proteases, neuroserpin, acts as a neuroprotective agent in a mouse model of neurodegenerative disease. J Neurosci. 26, 10614-9 (2006). 

Lebeurrier, N., Liot, G., Lopez-Atalaya, J. P., Orset, C., Fernandez-Monreal, M., Sonderegger, P., Ali, C. & Vivien, D. The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo. Mol. Cell. Neurosci. 30, 552-558 (2005).

Schrimpf, S. P., Meskenaite, V., Brunner, E., Rutishauser, D., Walther, P., Eng, J., Aebersold, R. & Sonderegger, P. Proteomic analysis of synaptosomes using isotope-coded affinity tags and mass spectrometry. Proteomics 5, 2531-2541 (2005).

Navarro-Yubero, C., Cuadrado, A., Sonderegger, P. & Munoz, A. Neuroserpin is post-transcriptionally regulated by thyroid hormone. Mol. Brain Res. 123, 56-65 (2004).

Madani, R., Kozlov, S., Akhmedov, A., Cinelli, P., Kinter, J., Lipp, H. P., Sonderegger, P. & Wolfer, D. P. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol. Cell. Neurosci. 23, 473-494 (2003).

Molinari, F., Meskanaite, V., Munnich, A., Sonderegger, P. & Colleaux, L. Extracellular proteases and their inhibitors in genetic diseases of the central nervous system. Human Mol. Genet. 12, R195-R200 (2003).

Wannier-Morino, P., Rager, G., Sonderegger, P. & Grabs, D. Expression of neuroserpin in the visual cortex of the mouse during the developmental critical period. Eur. J. Neurosci. 17, 1853-1860 (2003).

Cuadrado, A., Navarro-Yubero, C., Furneaux, H., Kinter, J., Sonderegger, P. & Munoz, A. HuD binds to three AU-rich sequences in the 3 '-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein. Nucleic Acids Res. 30, 2202-2211 (2002).

Hintsch, G., Zurlinden, A., Meskenaite, V., Steuble, M., Fink-Widmer, K., Kinter, J. & Sonderegger, P. The calsyntenins - A family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol. Cell. Neurosci. 21, 393-409 (2002).

Kunz, B., Lierheimer, R., Rader, C., Spirig, M., Ziegler, U. & Sonderegger, P. Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction. J. Biol. Chem. 277, 4551-4557 (2002).

Molinari, F., Rio, M., Meskenaite, V., Encha-Razavi, F., Auge, J., Bacq, D., Briault, S., Vekemans, M., Munnich, A., Attie-Bitach, T., Sonderegger, P. & Colleaux, L. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science 298, 1779-1781 (2002).

Alvarez-Dolado, M., Figueroa, A., Kozlov, S., Sonderegger, P., Furley, A. J. & Munoz, A. Thyroid hormone regulates TAG-1 expression in the developing rat brain. Eur. J. Neurosci. 14, 1209-1218 (2001).

Bernard, A., Fitzli, D., Sonderegger, P., Delamarche, E., Michel, B., Bosshard, H. R. & Biebuyck, H. Affinity capture of proteins from solution and their dissociation by contact printing. Nat. Biotechnol. 19, 866-869 (2001). 

Briand, C., Kozlov, S. V., Sonderegger, P. & Grutter, M. G. Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease. Febs Lett. 505, 18-22 (2001).

Cinelli, P., Madani, R., Tsuzuki, N., Vallet, P., Arras, M., Zhao, C. N., Osterwalder, T., Rulicke, T. & Sonderegger, P. Neuroserpin, a neuroprotective factor in focal ischemic stroke. Mol. Cell. Neurosci. 18, 443-457 (2001).

Modestin, J., Sonderegger, P. & Erni, T. Follow-up study of hysterical psychosis, reactive/psychogenic psychosis, and schizophrenia. Comprehensive Psychiatry 42, 51-56 (2001).

Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Freigang, J., Rader, C., Sonderegger, P. & Brummendorf, T. The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. Mol. Cell. Neurosci. 18, 91-107 (2001).

Silverman, M. A., Kaech, S., Jareb, M., Burack, M. A., Vogt, L., Sonderegger, P. & Banker, G. Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture. Proc. Natl. Acad. Sci. USA 98, 7051-7057 (2001).

Sorribas, H., Braun, D., Leder, L., Sonderegger, P. & Tiefenauer, L. Adhesion proteins for a tight neuron-electrode contact. J. Neurosci. Meth. 104, 133-141 (2001).

Vogt, L., Schrimpf, S. P., Meskenaite, V., Frischknecht, R., Kinter, J., Leone, D. P., Ziegler, U. & Sonderegger, P. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol. Cell. Neurosci. 17, 151-166 (2001).

Wolfer, D. P., Lang, R., Cinelli, P., Madani, R. & Sonderegger, P. Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern. Mol. Cell. Neurosci. 18, 407-433 (2001).