Publikationen 2007

Alioth, S., Meyer, S., Dutzler, R., & Pervushin, K. The Cytoplasmic Domain of the Chloride Channel ClC-0: Structural and Dynamic Characterization of Flexible Regions. J. Mol. Biol. 369,1163-1169 (2007).

Best, RB., Merchant, KA., Gopich, IV., Schuler, B., Bax, A. & Eaton, WA. Effect of flexibility and cis residues in single-molecule FRET studies of polyproline. PNAS U.S.A. 104, 18964-18969 (2007).

Bragg, J.G. &  Wagner A. Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes. Proc. Biol. Sci. 274, 1063-70 (2007).

Braun, O., Knipp, M., Chesnov, S., and Vasak, M. Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dmethylargininase-1 and CTP synthetase, Protein Sci. 16, 1522-1534 (2007).

Ciliberti, S, Martin, OC & Wagner, A. Innovation and robustness in complex regulatory gene networks. PNAS U.S.A. 104, 13591-13596 (2007).

Ciliberti, S, Martin, OC & Wagner, A. Robustness can evolve gradually in complex regulatory networks with varying topology. PLoS Computational Biology 3(2), e15 (2007).

Cui, T., Gao, Y., Puah, CM & Gutte, B. Efficient preparation of an acyclic permutant of kalata B1 from a recombinant fusion protein with thioredoxin. J. Biotechnol. 130, 378-384 (2007).

Dutzler R. A structural perspective on ClC channel and transporter function. FEBS Lett. 581, 2839-2844 (2007).

Friedmann, R. & Caflisch, A. The protonation state of the catalytic aspartates in plasmepsin II. FEBS Lett. 581, 4120-4124 (2007).

Galliciotti, G., Glatzel, M., Kinter, J., Kozlov, SV., Cinelli, P., Rulicke, T. & Sonderegger, P. Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am. J. Pathol. 170, 1305-13 (2007).

Gemperli, A.C., Schaffitzel, C., Jacob, C. & Steuber, J. Transport of Na+ and K+ by an antiporter-related subunit from the Escherichia coli NADH dehydrogenase I produced in Saccharomyces cerevisiae. Arch. Microbiol. 188, 509-521 (2007).  

Georgiev, O. & Jelesarov, I. Energetics of peptide recognition by the second PDZ domain of human protein tyrosine phosphatase 1E. Biochemistry 46, 1064-1078 (2007). 

Gfeller, D.,  De Los Rios, P . Caflisch, A.  &  Rao, F. Complex network analysis of free-energy landscapes. PNAS U.S.A. 104,1817-1822 (2007).

Gorfe, A. & Caflisch, A. Ser170 controls the conformational multiplicity of the loop 166-175 in prion proteins: Implication for conversion and species barrier. FASEB J. 21, 3279-32787 (2007).

Göschke, R., Stutz, Rasetti V., Cohen, NC., Rahuel , J., Rigollier, P., Baum, HP., Forgiarini, P., Schnell, CR., Wagner, T., Grütter, MG., Fuhrer, W., Schilling, W., Cumin, F., Wood, JM. & Maibaum, J. Novel 2.7-dialkyl-substituted 5 (S) amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin. J. Med.Chem. 50, 4818-4831 (2007).

Gourfinkel-An, I., Duyckaerts, C., Camuzat, A., Meyrignac, C., Sondergger, P., Baulac, M. & Brice, A. Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. Neurology 69, 79-83 (2007).

Hillger, F., Nettels, D., Dorsch, S. & Schuler B. Detection and Analysis of Protein Aggregation with Confocal Single Molecule Fluorescence Spectroscopy. J. Fluoresc. 17, 759-765 (2007).

Hoffmann, A., Kane, A.,Nettels, D., Hertzog, D., Baumgärtel, P., Lengefeld, J., Reichardt, G., Horsley, D.A., Seckler, R., Bakajin, O & Schuler, B. Mapping protein collapse with single molecule fluorescence and kinetic synchrotron radiation circular dichroism spectroscopy. PNAS U.S.A. 104, 105-110 (2007).

Huber, T., Steiner, D., Rothlisberger, D., Plückthun, A. In vitro selection and characterization of DARPins and Fab fragments for the co-crystallization of membrane proteins: The Na(+)-citrate symporter CitS as an example. J. Struct. Biol. 159, 206-211 (2007).

Hussain, S., Plückthun, A., Allen, TM. & Zangenmeister-Wittke, U. Antitumor activity of an epithelial cell adhesion molecule targeted nanovesicular drug delivery system. Mol. Cancer Ther. 6, 3019-3027 (2007).

Jelesarov, I. & Bosshard, HR. Isothermal titration calorimetry in studies of protein binding and protein conformational transitions. In "Protein Structures: Methods in Protein Structure Analysis." (Uversky, V. N. and E. A. Permyakov, Eds.), Nova Science Publishers, Inc., Hauppauge, N. Y. Chapter 1.2, pp. 29-55 (2007).

Knipp, M., Karotki, A. V., Chesnov, S., Natile, G., Sadler, P.J., Brabec, V., and Vasak, M. The reaction of Zn₇metallothionein with cis- and trans-[Pt(N-donor)₂Cl₂] anticancer complexes: Trans-Pt^II complexes retain their N-donor ligands. J. Med. Chem. 50, 4075-4086 (2007).

Koch, M., Bhattacharya, S., Kel, T., Gimona, M., Vasak, M., Chazin, W., Heizmann, C.W., Kroneck, P.M. & Fritz, G. Implications on zinc binding to S100A2. Biochim. Biophys. Acta. 1773, 457-70 (2007).

Kolly,R., Thiel, M.A., Herrmann, T. & Plückthun, A. Monovalent antibody scFv fragments selected to modulate T-cell activation by inhibition of CD86-CD28 interaction. Protein Eng. Des. Sel. 20, 91-98 (2007).
Lin, P.-C.,Türk, K.,Häse, C.C.,Fritz, G.& Steuber, J. Quinone reduction by the Na+ -translocating NADH dehydrogenase (Na+-NQR) promotes extracellular superoxide production in Vibrio cholerae. J. Bacteriol. 189, 3902-3908 (2007).

Maibaum J., Stutz, S., Göschke, R., Rigollier, P., Yamaguchi, Y., Cumin, F., Rahuel, J., Baum, HP., Cohen, NC., Schnell, C., Fuhrer, W., Grütter, M., Schillinh, W. & Wood, J. Structural modification of the P2' position of 2,7-dialkyl-substituted 5 (S) amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. J. Med.Chem. 50, 4832-4844 (2007).

Markovic, S. & Dutzler, R. The Structure of the Cytoplasmic Domain of the Chloride Channel ClC-Ka Reveals a Conserved Interaction Interface. Structure 15, 715-725 (2007).

Meyer-Andrejszki, L., Bjelic, S., Naud, JF., Lavigne, P. & Jelesarov, I.Thermodynamics of b-HLH-LZ protein binding to DNA: the energetic importance of protein-DNA contacts in site-specific E-box recognition by the complete gene product of the Max p21 transcription factor. Biochemistry 46, 12427-12440 (2007).

Meloni G., Faller P. & Vasak M.   Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions. J. Biol. Chem. 282, 16068-16078 (2007).

Meyer S., Savaresi S., Forster I.C. & Dutzler R. Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5. Nat. Struct. Mol. Biol. 14, 60-67 (2007).