Publications of the Grütter group

Bonnet, M., Kurz, M., Mesa, S., Briand, C., Hennecke, H. & Grütter, MG. Structure of Bradyrhizobium japonicum transcription factor FixK2 unveils sites of DNA binding and oxidation. J Biol.Chem. 2013 Apr 1. [Epub ahead of print]

Bukowska, MA. & Grütter, MG. New concepts and aids to facilitate crystallization. Curr Opin Struct Biol. 2013 Apr 8 [Epub ahead of print]

Dreier, B., Honegger, A., Hess, C., Nagy-Davidescu, G., Mittl, PR., Grütter, MG., Belousova, N., Mekheeva, G., Krasnykh, V. & Plückthun, A. Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. PNAS USA 110, E869-877 (2013).

Hausammann, GJ., Heitkamp, T., Matile, H., Gsell, B., Thoma, R., Schmid, G., Frasson, D., Sievers, M., Hennig, M. & Grütter, MG. Generation of an antibody toolbox to characterize hERG. Biochem Biophys Res Commun. 431, 70-75 (2013).

Schröder, T., Barandun, J., flütsch, A., Briand, C., Mittl, PR. & Grütter, MG. Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors. Structure 21, 277-289 (2013).

Chodorge, M., Züger, S., Stirnimann, C., Briand, C., Jermutus, L., Grütter, MG. & Minter, RR. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Diff. 19, 1187-1195 (2012).

Crespo, MD., Puorger, C., Schärer, MA., Eidam, O., Grütter, MG., Capitani, G. & Glockshuber, R. Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. Nat Chem Biol. 8, 707-713 (2012).

Eicher,T., Cha, HJ., Seeger, MA., Brandstätter, L., El-Delik, J., Bohnert, JA., Kern WV., Verrey, F., Grütter, MG., Diederichs, K. & Pos, KM. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. PNAS 109, 5687-5692 (2012). 

Grütter, MG & Luban, J.TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. Curr Opin Virol. 2, 142-150 (2012).

Heck,T., Merz, T., Reimer, A., Seebach, D., Rentsch, D., Briand, C., Grütter, MG., Kohler, HP. & Geueke, B. Crytsal structure of BapA complexes with beta-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of beta-aminopeptidases. Chembiochem. 13, 2137-2145 (2012).

Hohl M., Grütter MG. & Seeger MA. X-ray structure of a heterodimeric ABC transporter crystallized in its inward-facing conformation. Chimia (Aarau)66, 802 (2012).

Hohl, M., Briand, C., Grütter, MG. & Seeger, M. Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol. 19, 395-402 (2012).

Kebbel, F., Kurz, M., Grütter, M. & Stahlberg, H. Projection structure of the secondary citrate/sodium symporter CitSat 6 Angstroem resolution by electron crystallography. J Mol Biol. 418, 117-126 (2012).

Madhurantakam, C., Varadamsetty, G., Grütter, MG., Plückthun, A. & Mittl, PR. Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci. 21, 1015-1028 (2012).

Merz,T., Heck, T. Geueke, B., Mittl, PR., Briand, C., Seebach, D., Kohler, HP. & Grütter, MG. Autoproteolytic and catalytic mechanisms for the beta-aminopeptidase BapA- a member of the Ntn hydrolase family. Structure 20, 1850-1860 (2012).

Mittal, A., Boehm, S., Grütter, MG., Bordignon, E. & Seeger, MA. Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin. J Biol Chemistry 287, 20395-20406 (2012).

Roschitzki-Voser, H., Schröder, T-. Lenherr, ED., Frölich, F., Schweizer, A., Donepudi, M., Ganesan, R., Mittl, PR., Baici, A. & Grütter, MG. Human caspases in vitro: expression, purification and kinetic characterization. Protein Expr Purif. 84, 236-246 (2012).

Seeger, MA., Mittal, A., Velamakanni, S., Hohl, M., Schauer, S., Salaa, I., Grütter, MG. & van Veen, HW. Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders. PLoS One 7(6):e37845 (2012).

Bourquin, F., Capitani, G. & Grütter, MG. PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci. 20, 1492-1508 (2011). 

Devi, VS, & Mittl. PR. Monitoring the disulfide bond formation of a cysteine-rich repeat proteine from Helicobacter pylori in the periplasm of escherichia coli. Curr Microbiol. 62, 903-907 (2011).

Flütsch, A., Schröder, T., Grütter MG. & Patzke, GR. HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorg. Med. Chem. Lett. 21, 1162-1166 (2011).

Ganesan, R., Jelakovic, S., Mittl, PR., Caflisch, A. & Grütter, MG. In silico identification and crystal structure validation of procaspase-3 inhibitors without a P1 aspartic acid moiety. Acta Crystallogr SectF Struct Biol Cryst Commun. 67(Pt8), 842-850 (2011).

Huwiler, A., Bourquin, F., Kotelevets, N., Pastukhov, O., Capitani, G., Grütter, MG. & Zangemeister-Wittke, U. A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLoS One. 6(8): e22436 (2011). 

Monroe, N., Sennhauser, G., Seeger, M., Briand, C. & Grütter, MG. Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface. J. Struct. Biol. 174, 269-281 (2011).

Pertel, T.,Hausmann, S., Morger, D., Züger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, FA., Uchil, PD., Chatel, L., Bisiaux, A., Albert, ML., Strambio-De-Castillia, C., Mothes, W., Pizzato, M., Grutter, MG. & Luban, J. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361-365 (2011). 

Roschitzki, B.,Schauer, S. & Mittl, PR. Recognition of host proteins by Helicobacter cysteine-rich proteine C. Curr Microbiol. 63, 239-249 (2011).

Schärer, MA., Eliot, AC., Grütter, MG. & Capitani, G. Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy . FEBS Lett. 585, 111-114 (2011). 

Bourquin, F., Riezman, H., Capitani, G. & Grütter, M. Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 18, 1054-1065 (2010).

Keller, N., Grütter, MG. & Zerbe, O.Studies of the molecular mechanism of caspase-8 activation by solution NMR. Cell Death Differ. 17, 710-718 (2010).

Kindermann, M., Roschitzki-Voser, H., Caglic, D., Repnik, U., Miniejew, C., Mittl, PR., Kosec, G., Grütter, MG., Turk, B.& Wendt, KU. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 17, 999-1007 (2010).

Kramer, MA., Wetzel, SK:, Plückthun, A., Mittl, PR. & Grütter, MG. Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned c-capping module. J Mol Biol. 404, 381-391 (2010).

Melkko S, Mannocci L, Dumelin CE, Villa A, Sommavilla R, Zhang Y, Grütter MG, Keller N, Jermutus L, Jackson RH, Scheuermann J & Neri D. Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library. Chem Med Chem. 5, 584-590 (2010).

Pham,QT., Bouchard, A., Grütter, MG. & Berthoux, L. Generation of human TRIM5alpha mutants with high HIV-1 restriction acitivity. Gene Ther. 17, 859-871 (2010).

Schärer, MA., Grütter, MG. & Capitani, G. CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts. Proteins 78, 2707-2713 (2010).

Schoep,TD., Fulurija, A., Good, F., Lu, W., Hirnbeck, RP., Schwan, C., Choi, SS., Berg, DE., Mittl, PR., Benghezal, M. & Marshall, BJ. Surface properties of Helicobacter pylori urease complex are essential for persistence. PLoS One. 5 (11): e15042 (2010).

Baumgartner, R., Meder, G. , Briand, C., Decock, A., D'arcy, A., Hassiepen, U., Morse, R. & Renatus, M. The crystal structure of caspase-6, a selective effector of axonal degeneration. Biochem. J. 423, 429-439 (2009).

Dumrese, C., Slomianka, L., Ziegler, U., Choi, SS., Kalia, A., Fulurija, A., Lu, W., Berg, DE., Benghezal, M. , Marshall, B. & Mittl, PR. The secreted Heliobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype. FEBS Lett. 583, 1637-1643 (2009).

Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grütter MG & Capitani G. A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol. 392, 334-351 (2009). 

Keller, N., Mares, J., Zerbe, O. & Grütter, MG. Structural and biochemical studies on procaspase-8: new insights on initiator caspase inactivation. Structure 17, 438-448 (2009).

Neagu, MR., Ziegler, P., Pertel, T., Strambio-De-Castillia, C., Grütter, C., Martinetti, G., Mazzucchelli, L., Grütter, M., Manz, MG. &  Luban, J. Potent inhibition of HIV-1 by TRIM5-cylophilin fusion proteons engineered from human components. J Clin Invest. 119, 3035-3047 (2009).

Schulz BL, Stirnimann CU, Grimshaw JP, Brozzo MS, Fritsch F, Mohorko E, Capitani G, Glockshuber R, Grütter MG & Aebi M. Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc Natl Acad Sci U S A. 106, 11061-11066 (2009).

Sebastian, S., Grütter, C., Strambio de Castillia, C., Pertel, T., Olivari, S., Grütter, M. & Luban, J. An invariant surface patch on the TRIM5(alpha) PRYSPRY domain is required for retroviral restriction but dispensable for capsid-binding. J. Virol. 83, 3365-3373 (2009).

Sennhauser, G., Bukowska, MA., Briand, C. & Grütter, MG. Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. J Mol Biol 389, 134-145 (2009).